The Neuropeptide α-Melanocyte-Stimulating Hormone Prevents Persistent Corneal Edema Following Injury
- rani mizrahi
- Oct 29
- 1 min read
An article published in The American Journal of Pathology presents new findings regarding the ability of the neuropeptide α-MSH (α-Melanocyte–Stimulating Hormone) to preserve corneal endothelial function after injury.
The corneal endothelial cells are responsible for regulating fluids and maintaining tissue transparency, but their ability to regenerate is extremely limited. Currently, corneal transplantation is the only therapeutic option for restoring endothelial function, and there is still no dedicated drug treatment.
In a study conducted in a mouse model using cryoinjury, it was found that topical administration of α-MSH after the injury prevented corneal edema and opacity, reduced inflammatory cell infiltration, and reduced endothelial cell death – while encouraging their proliferation.
The findings suggest that α-MSH may serve as a pro-regenerative therapy and protective factor, providing a promising alternative for the prevention and treatment of corneal endothelial dysfunction.
