The research deals with the development of a new, multidimensional drug based on inhibitory small molecules for the treatment of retinal and vascular diseases such as diabetic retinopathy, wet age-related macular degeneration, and venous occlusions. We were able to demonstrate using cell cultures, tissues, and an animal model that our new compound, which works through a combined mechanism that is different from current treatments in clinical use, is highly effective in suppre
Sapir presented her research on the genetics of retinal diseases - finding new genes and mutations that cause these diseases and developing genetic therapies.
In a study conducted at Hadassah Medical Center in collaboration with the Jerusalem Multidisciplinary Academic Center, data from 557 cataract surgeries performed by ophthalmology residents (2018–2022) were analyzed. The aim of the study was to identify factors that predict non-clinically significant improvement in visual acuity (BCVA) after surgery, using machine learning models to create a personalized prediction tool. It was found that in 23% of patients, the improvement in
